MCF10A dCAS9-VPR
MCF10A dCAS9-VPR
Not specified
Not specified
MCF10A-CRISPRa
Selection with 500 µg/ml G418
Vector expression dCas9-VPR
wild-type
Views: 6685
Created: 20th Oct 2022 at 04:49
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I consider myself a "systems biologist", trained in a variety of different areas, but primarily interested in how organisms work as integrated, self-regulating systems. Trained in protein chemistry and cell biology, I have extensive experience in modeling biological systems as well as image analysis and other novel analytical technologies. Currently, my major focus is on integrating multiple types of 'omics data to provide insight into fundamental biological regulatory mechanisms.
A major aim of cancer systems biology is to build models that can predict the impact of these genetic disruptions to guide therapeutic interventions. A prominent driver of cancer cell growth is signaling pathway deregulation from mutations in key regulatory nodes and loss/gain in gene copy number (CNV). Recent work by our group discovered that the abundances of most signaling pathway proteins are highly conserved with signaling being controlled by only a few, low abundance key nodes. The activity ...
Public web page: https://csbconsortium.org/research-projects/reverse-sensitivity-analysis-for-identifying-predictive-proteomics-signatures-of-cancer/
Start date: 1st Apr 2019
End date: 30th Apr 2024
