Homo sapiens

Details about this organism

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Strain details

Name Provider name Provider's strain ID Genotypes Phenotypes Synonym Comments Based on
MCF 10A ATCC CRL-10317 wild-type Epithelial MCF-10A The MCF 10A cell line is a non-tumorigenic epithelial cell line. The cells are positive for epithelial sialomucins, cytokeratins and milk fat globule antigen. They exhibit three dimensional growth in collagen, and form domes in confluent cultures. Thus far, the cells have shown no signs of terminal differentiation or senescence. The line is responsive to insulin, glucocorticoids, cholera enterotoxin, and epidermal growth factor (EGF). By electron microscopy the cells display characteristics of luminal ductal cells but not of myoepithelial cells. They also express breast specific antigens as detected by positive reaction with MFA-Breast and MC-5 monoclonal antibodies. The calcium content of the medium exerts a strong effect on the morphology of the cells. Not specified
MCF10A dCAS9-VPR Not specified Not specified Vector expression dCas9-VPR wild-type MCF10A-CRISPRa Selection with 500 µg/ml G418 MCF 10A
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